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KLINE, KIMBERLY

Kimberly Kline

Professor Emeritus
Department of Nutritional Sciences

Julian C. Barton Professorship in Nutrition

k.kline@austin.utexas.edu


Postal Address
103 W 24TH ST
, TX 78712

Ph.D., Nutritional Sciences, University of Texas at Austin

Research Interests

Dr. Kline’s research interests are in the interdisciplinary areas of nutrition and cancer biology. Long term goals are to better our understanding of the biological actions of vitamin E, both naturally occurring forms and synthetic derivatives of vitamin E. Current investigations involve understanding the role of certain vitamin E compounds as tumor cell growth inhibitors. Cellular, biochemical and molecular mechanisms of vitamin E’s actions in inhibiting cell proliferation and stimulating programmed cell death (apoptosis) are under study.

PUBLICATIONS

Articles (Peered Reviewed Journal Articles):

(Current 10 year period)

Tiwary, R., W. Yu, L. A. deGraffenried, B. G. Sanders and K. Kline. 2011. Targeting cholesterol-rich microdomains to circumvent tamoxifen-resistant breast cancer. Breast Cancer Research. 13 (6):R120 doi10.1186/bcr3060.

Tiwary, R., W. Yu, B. G. Sanders and K. Kline. 2011. a-TEA cooperates with MEK or mTOR inhibitors to induce apoptosis via targeting IRS/PI3K pathways. British Journal of Cancer. 104: 101-109.

Tiwary, R., W. Yu, B. G. Sanders and K. Kline. 2011. α-TEA cooperates with chemotherapeutic agents to induce apoptosis of p53 mutant, triple negative human breast cancer cells via activating p73. Breast Cancer Research. 13:R1 http://breast-cancerresearch.com/content/13/1/R1.

Yu, W., R. Tiwary, J. Li, S- K. Park, L. Jia., M. Simmons-Menchaca, B. G. Sanders, and K. Kline, 2010. alpha-TEA induces apoptosis of human breast cancer cells via activation of TRAIL/DR5 death receptor pathway. Molecular Carcinogenesis. 49: 964-973.

Li, J., W. Yu, R. Tiwary, S-K. Park, A. Xiong, B. G. Sanders, and K. Kline. 2010. α-TEA-induced death receptor dependent apoptosis involves activation of acid sphingomyelinase and elevated ceramide-enriched cell surface membranes. Cancer Cell International. 10:40; http:www.cancerci.com/content/10/1/40.

Tiwary, R., W. Yu, J. Li, S- K. Park, B. G. Sanders, and K. Kline. 2010. Role of endoplasmic reticulum stress in α-TEA-mediated TRAIL/DR5 death receptor dependent apoptosis. PLoS ONE. Published online July 29, 2010:
http://dx.plos.org/10.1371/journal.pone.0011865.

Park, S. K., B. G. Sanders and K. Kline. 2010. Tocotrienols induce apoptosis in breast cancer cell lines via an endoplasmic reticulum stress-dependent increase in extrinsic death receptor signaling. Breast Cancer Research and Treatment. DOI 10.1007/s10549-010-0786-2 Published online 16 February 2010.

Shun, M-C., W. Yu, S-K. Park, B. G. Sanders and K. Kline. 2010. Downregulation of epidermal growth factor receptor expression contributes to a-TEA's pro-apoptotic effects in human ovarian cancer cell lines. Journal of Oncology. Vol.
2010, Article ID 824571, 11 pages, doi:10.1155/2010/824571.

Latimer, P., M. Menchaca, R. M. Snyder, W. Yu, B. E. Gilbert, B. G. Sanders and K. Kline. 2009. Aerosol delivery of liposomal formulated paclitaxel and vitamin E analog reduces murine mammary tumor burden and metastases. Experimental Biology and Medicine. 234:1244-1252.

Yu, W., L. Jia, S-K. Park, J. Li, A. Gopalan, M. Simmons-Menchaca, B. G. Sanders and K. Kline. 2009. Anticancer actions of natural and synthetic vitamin E forms: RRR-α-tocopherol blocks the anticancer actions of g-tocopherol. Molecular
Nutrition and Food Research. 53: 1573-1581.

Yu, W., S. K. Park, L. Jia,, R. Tiwary, W. W. Scott, J. Li, P. Wang, M. SimmonsMenchaca, B. G. Sanders and K. Kline. 2008. RRR-γ-tocopherol induces human breast cancer cells to undergo apoptosis via death receptor 5 (DR5)-mediated apoptotic signaling. Cancer Letters. 259(2): 165-176.

Riedel, S. B., S. M. Fischer, B. G. Sanders, and K. Kline. 2008. Vitamin E analog, alpha-tocopherol ether-linked acetic acid analog, alone and in combination with celecoxib, reduces multiplicity of ultraviolet-induced skin cancers in mice. Anti-Cancer Drugs. 19(2): 175-181.

Snyder, R. M., W. Yu, L. Jia, B. G. Sanders, and K. Kline. 2008. Vitamin E analog α-TEA, methylseleninic acid, and trans-resveratrol in combination synergistically inhibit human breast cancer cell growth. Nutrition and Cancer. 60(3): 401-411.

Wang, P., W. Yu, Z. Hu, L. Jia, V. R. Iyer, B. G. Sanders, and K. Kline. 2008. Involvement of JNK/p73/NOXA in vitamin E analog-induced apoptosis of human breast cancer cells. Molecular Carcinogenesis. 47:436-445.

Yu, W., L. Jia, P. Wang, K. A. Lawson, M. Simmons-Menchaca, S-K. Park, LZ. Sun, B. G. Sanders, and K. Kline. 2008. In vitro and in vivo evaluation of anticancer actions of natural and synthetic vitamin E forms. Molecular Nutrition and Food
Research. 52: 447-456.

Jia, L., W. Yu, P. Wang, J. Li, B. G. Sanders, and K. Kline. 2008. Critical roles for JNK, c-Jun and Fas/FasL-signaling in vitamin E analog-induced apoptosis in human prostate cancer cells. The Prostate. 68:427-441.

Jia, L., W. Yu, P. Wang, B. G. Sanders, and K. Kline. 2008. In vivo and in vitro studies of anticancer actions of alpha-TEA for human prostate cancer cells. The Prostate. 68: 849-860.

Wang, P., L. Jia, B. G. Sanders, and K. Kline. 2007. Liposomal or nanoparticle α-TEA reduced 66cl-4 murine mammary cancer burden and metastasis. Drug Delivery. 14 (8):497-505.

Yu, W., M. C. Shun, K. Anderson, H. Chen, B. G. Sanders, and K. Kline. 2006. α-TEA inhibits survival and enhances death pathways in cisplatin sensitive and resistant human ovarian cancer cells. Apoptosis. 11: 1813-1823.

Anderson, K., K. A. Lawson, M. Simmons-Menchaca, L-Z. Sun, B. G. Sanders and K. Kline. 2004. α-TEA plus cisplatin reduces human cisplatin-resistant ovarian cancer cell tumor burden and metastasis. Experimental Biology and Medicine. 229: 1169-1176.

Lawson, K.A., K. Anderson, M. Menchaca, J. Atkinson, L-Z. Sun, B. G. Sanders, and K. Kline. 2004. Comparison of vitamin E derivatives, α-TEA and VES in reduction of mouse mammary tumor burden and metastasis. Experimental Biology and Medicine. 229: 954-963.

Lawson, K. A., K. Anderson, R. M. Snyder, M. Simmons-Menchaca, J. Atkinson, L-Z. Sun, A. Bandyopadhyay, V. Knight, B. E. Gilbert, B. G. Sanders and K. Kline. 2004. Novel vitamin E analogue and 9-nitro-camptothecin administered as liposome aerosols decrease syngeneic mouse mammary tumor burden and inhibit metastasis. Cancer
Chemotherapy and Pharmacology. 54:421-431.

Zhang, S., K. A. Lawson, M. Simmons-Menchaca, L-Z. Sun, B. G. Sanders, and K. Kline. 2004. Vitamin E analog α-TEA and celecoxib alone and together reduce human MDA-MB-435-FL-GFP breast cancer burden and metastasis in nude mice. Breast Cancer Research and Treatment. 87:111-121.

Anderson, K., M. Simmons-Menchaca, K. A. Lawson, J. A. Atkinson, B. G. Sanders and K. Kline. 2004. Differential response of human ovarian cancer cells to induction of apoptosis by vitamin E succinate and vitamin E analog, α-TEA. Cancer Research. 64:4263-4269.

Shun, M-C., W. Yu, A. Gapor, R. Parsons, J. Atkinson, B. G. Sanders, and K. Kline. 2004. Pro-apoptotic mechanisms of action of a novel vitamin E analog (α-TEA) and a naturally occurring form ofvitamin E (δ-tocotrienol) in MDA-MB-435 human breast cancer cells. Nutrition and Cancer. 48:95-105.

Yu, W., B. G. Sanders and K. Kline. 2003. RRR-α-tocopheryl succinate-induced apoptosis of human breast cancer cells involves Bax translocation to mitochondria. Cancer Research. 61: 2483-2491.Lawson, K.A., K. Anderson, M. Menchaca, J. Atkinson, L-Z. Sun, V. Knight, B.

E. Gilbert, C. Conti, B. G. Sanders, and K. Kline. 2003. Novel vitamin E analog decreases syngeneic mouse mammary tumor burden and reduces lung metastasis. Molecular Cancer Therapeutics 2: 437-444.

Yu, W., B. G. Sanders and K. Kline. 2002. RRR-α-tocopheryl succinate induction of DNA synthesis arrest of human MDA-MB-435 cells involves TGF-β independent activation of p21 (Waf1/Cip1). Nutrition and Cancer. 43: 227-236.

You, H., W. Yu, D. Munoz-Medellin, P. H. Brown, B. G. Sanders, and K. Kline. 2002. Role of extracellular signal-regulated kinase pathway in RRR-alpha-tocopheryl succinate-induced differentiation of human MDA-MB-435 breast cancer cells. Molecular Carcinogenesis 4: 228-236.