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Bobby G Sanders
Professor Emeritus
Molecular Biosciences-
Research Summary:
Research interests are in the interdisciplinary areas of nutrition and cancer biology. Long term goals are to develop vitamin E analogs as anticancer agents, and to increase the understanding of the biological actions of vitamin E, both naturally occurring forms and synthetic analogs. Current investigations involve conducting chemotherapeutic studies with a vitamin E analog referred to as alpha-TEA, using syngeneic and xenograft preclinical animal models. Cell and molecular studies are focused on understanding signaling networks involved in alpha-TEA's pro-apoptotic and anti-survival mediated anti-cancer effects.
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Publications:
2014 Kline, K., W. Yu, R. Tiwary, and B. G. Sanders. Vitamin E family of compounds and cancer prevention. In: Inflammation, Oxidative Stress, and Cancer: Dietary Approaches for Cancer Prevention. A.-N.Tony Kong, editor. CRC Press. Pages 243-260. Invited Review.
2013 Gopalan, A., W. Yu, B. G. Sanders and K. Kline. Eliminating drug resistant breast cancer stem-like cells with combination of simvastatin and gamma-tocotrienol. Cancer Letters. 328(2):285- 296.
2012 Chen, W. S. K. Park, W. Yu, A. Xiong, B. G. Sanders, and K. Kline. Synthesis and screening of novel vitamin E derivatives for anticancer functions. European Journal of Medicinal Chemistry. 58:72-83.
2012 Gopalan, A., W. Yu, B. G. Sanders and K. Kline. Simvastatin inhibition of mevalonate pathway induces apoptosis in human breast cancer cells via activation of JNK/CHOP/DR5 signaling pathway. Cancer Letters. 329(1):9-16.
2012 Gopalan, A., W. Yu, Q. Jiang, Y. Jang, B. G. Sanders and K. Kline. Involvement of de novo ceramide synthesis in gamma-tocopherol and gamma-tocotrienol-induced apoptosis in human breast cancer cells. Molecular Nutrition & Food Research. 56(12):1803-1811.
2012 Xiong, A., W. Yu, R. Tiwary, B. G. Sanders and K. Kline. Distinct role of different forms of vitamin E in DHA-induced apoptosis in triple negative breast cancer cells. Molecular Nutrition and Food Research. 56(6):923-934.
2011 Tiwary, R., W. Yu, L. A. deGraffenried, B. G. Sanders and K. Kline. Targeting cholesterol-rich microdomains to circumvent tamoxifen-resistant breast cancer. Breast Cancer Research. 13(6):R120 doi10.1186/bcr3060.
2011 Tiwary, R., W. Yu, B. G. Sanders and K. Kline. a-TEA cooperates with MEK or mTOR inhibitors to induce apoptosis via targeting IRS/PI3K pathways. British Journal of Cancer. 104:101-109.
2011 Tiwary, R., W. Yu, B. G. Sanders and K. Kline. a-TEA cooperates with chemotherapeutic agents to induce apoptosis of p53 mutant, triple negative human breast cancer cells via activating p73. Breast Cancer Research. 13:R1 http://breast-cancer-research.com/content/13/1/R1.
2008 Yu W, Park SK, Jia L, Tiwary R, Scott WW, Li J, Wang P, Simmons-Menchaca M, Sanders BG, Kline K, RRR-gamma-tocopherol induces human breast cancer cells to undergo apoptosis via death receptor 5 (DR5)-mediated apoptotic signaling, Cancer Lett 259: 165-76
2008 Riedel SB, Fischer SM, Sanders BG, Kline K, Anticancer Drugs, Anticancer Drugs 19: 175-81
2008 Jia L, Yu W, Wang P, Li J, Sanders BG, Kline K, Critical roles for JNK, c-Jun, and Fas/FasL-Signaling in vitamin E analog-induced apoptosis in human prostate cancer cells, Prostate 68: 427-41
2007 Kline K, Lawson KA, Yu W, Sanders BG, Vitamin E and cancer, Vitam Horm 76: 435-61
2007 Wang P, Jia L, Sanders BG, Kline K, Liposomal or nanoparticle alpha-TEA reduced 66cl-4 murine mammary cancer burden and metastasis, Drug Deliv 14: 497-505
2007 Wang P, Yu W, Hu Z, Jia L, Iyer VR, Sanders BG, Kline K, Involvement of JNK/p73/NOXA in vitamin E analog-induced apoptosis of human breast cancer cells, Mol Carcinog in press:
2006 Yu, W., M-C. Shun, K. Anderson, H. Chen, B. G. Sanders, and K. Kline, a-TEA inhibits survival and enhances death pathways in cisplatin sensitive and resistant human ovarian cancer cells, Apoptosis 11:
2004 Kline, K., W. Yu, and B. G. Sanders, Vitamin E and Breast Cancer, Journal of Nutrition 134:
2004 Lawson, K.A., K. Anderson, M. Menchaca, J. Atkinson, L-Z. Sun, B.G. Sanders, and K. Kline, Comparison of vitamin E derivatives, a-TEA and VES in reduction of mouse mammary tumor burden and metastasis, Experimental Biology and Medicine 229: 954-963
2004 Anderson, K., K.A. Lawson, M. Simmons-Menchaca, L-Z. Sun, B.G. Sanders and K. Kline, a-TEA plus cisplatin reduces human cisplatin-resistant ovarian cancer cell tumor burden and metastasis., Experimental Biology and Medicine. 229: 1169-1176
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