PUBLICATIONS

Articles (Peered Reviewed Journal Articles):

(Current 10 year period)

Tiwary, R., W. Yu, L. A. deGraffenried, B. G. Sanders and K. Kline. 2011. Targeting cholesterol-rich microdomains to circumvent tamoxifen-resistant breast cancer. Breast Cancer Research. 13 (6):R120 doi10.1186/bcr3060.

Tiwary, R., W. Yu, B. G. Sanders and K. Kline. 2011. a-TEA cooperates with MEK or mTOR inhibitors to induce apoptosis via targeting IRS/PI3K pathways. British Journal of Cancer. 104: 101-109.

Tiwary, R., W. Yu, B. G. Sanders and K. Kline. 2011. α-TEA cooperates with chemotherapeutic agents to induce apoptosis of p53 mutant, triple negative human breast cancer cells via activating p73. Breast Cancer Research. 13:R1 http://breast-cancerresearch.com/content/13/1/R1.

Yu, W., R. Tiwary, J. Li, S- K. Park, L. Jia., M. Simmons-Menchaca, B. G. Sanders, and K. Kline, 2010. alpha-TEA induces apoptosis of human breast cancer cells via activation of TRAIL/DR5 death receptor pathway. Molecular Carcinogenesis. 49: 964-973.

Li, J., W. Yu, R. Tiwary, S-K. Park, A. Xiong, B. G. Sanders, and K. Kline. 2010. α-TEA-induced death receptor dependent apoptosis involves activation of acid sphingomyelinase and elevated ceramide-enriched cell surface membranes. Cancer Cell International. 10:40; http:www.cancerci.com/content/10/1/40.

Tiwary, R., W. Yu, J. Li, S- K. Park, B. G. Sanders, and K. Kline. 2010. Role of endoplasmic reticulum stress in α-TEA-mediated TRAIL/DR5 death receptor dependent apoptosis. PLoS ONE. Published online July 29, 2010:
http://dx.plos.org/10.1371/journal.pone.0011865.

Park, S. K., B. G. Sanders and K. Kline. 2010. Tocotrienols induce apoptosis in breast cancer cell lines via an endoplasmic reticulum stress-dependent increase in extrinsic death receptor signaling. Breast Cancer Research and Treatment. DOI 10.1007/s10549-010-0786-2 Published online 16 February 2010.

Shun, M-C., W. Yu, S-K. Park, B. G. Sanders and K. Kline. 2010. Downregulation of epidermal growth factor receptor expression contributes to a-TEA's pro-apoptotic effects in human ovarian cancer cell lines. Journal of Oncology. Vol.
2010, Article ID 824571, 11 pages, doi:10.1155/2010/824571.

Latimer, P., M. Menchaca, R. M. Snyder, W. Yu, B. E. Gilbert, B. G. Sanders and K. Kline. 2009. Aerosol delivery of liposomal formulated paclitaxel and vitamin E analog reduces murine mammary tumor burden and metastases. Experimental Biology and Medicine. 234:1244-1252.

Yu, W., L. Jia, S-K. Park, J. Li, A. Gopalan, M. Simmons-Menchaca, B. G. Sanders and K. Kline. 2009. Anticancer actions of natural and synthetic vitamin E forms: RRR-α-tocopherol blocks the anticancer actions of g-tocopherol. Molecular
Nutrition and Food Research. 53: 1573-1581.

Yu, W., S. K. Park, L. Jia,, R. Tiwary, W. W. Scott, J. Li, P. Wang, M. SimmonsMenchaca, B. G. Sanders and K. Kline. 2008. RRR-γ-tocopherol induces human breast cancer cells to undergo apoptosis via death receptor 5 (DR5)-mediated apoptotic signaling. Cancer Letters. 259(2): 165-176.

Riedel, S. B., S. M. Fischer, B. G. Sanders, and K. Kline. 2008. Vitamin E analog, alpha-tocopherol ether-linked acetic acid analog, alone and in combination with celecoxib, reduces multiplicity of ultraviolet-induced skin cancers in mice. Anti-Cancer Drugs. 19(2): 175-181.

Snyder, R. M., W. Yu, L. Jia, B. G. Sanders, and K. Kline. 2008. Vitamin E analog α-TEA, methylseleninic acid, and trans-resveratrol in combination synergistically inhibit human breast cancer cell growth. Nutrition and Cancer. 60(3): 401-411.

Wang, P., W. Yu, Z. Hu, L. Jia, V. R. Iyer, B. G. Sanders, and K. Kline. 2008. Involvement of JNK/p73/NOXA in vitamin E analog-induced apoptosis of human breast cancer cells. Molecular Carcinogenesis. 47:436-445.

Yu, W., L. Jia, P. Wang, K. A. Lawson, M. Simmons-Menchaca, S-K. Park, LZ. Sun, B. G. Sanders, and K. Kline. 2008. In vitro and in vivo evaluation of anticancer actions of natural and synthetic vitamin E forms. Molecular Nutrition and Food
Research. 52: 447-456.

Jia, L., W. Yu, P. Wang, J. Li, B. G. Sanders, and K. Kline. 2008. Critical roles for JNK, c-Jun and Fas/FasL-signaling in vitamin E analog-induced apoptosis in human prostate cancer cells. The Prostate. 68:427-441.

Jia, L., W. Yu, P. Wang, B. G. Sanders, and K. Kline. 2008. In vivo and in vitro studies of anticancer actions of alpha-TEA for human prostate cancer cells. The Prostate. 68: 849-860.

Wang, P., L. Jia, B. G. Sanders, and K. Kline. 2007. Liposomal or nanoparticle α-TEA reduced 66cl-4 murine mammary cancer burden and metastasis. Drug Delivery. 14 (8):497-505.

Yu, W., M. C. Shun, K. Anderson, H. Chen, B. G. Sanders, and K. Kline. 2006. α-TEA inhibits survival and enhances death pathways in cisplatin sensitive and resistant human ovarian cancer cells. Apoptosis. 11: 1813-1823.

Anderson, K., K. A. Lawson, M. Simmons-Menchaca, L-Z. Sun, B. G. Sanders and K. Kline. 2004. α-TEA plus cisplatin reduces human cisplatin-resistant ovarian cancer cell tumor burden and metastasis. Experimental Biology and Medicine. 229: 1169-1176.

Lawson, K.A., K. Anderson, M. Menchaca, J. Atkinson, L-Z. Sun, B. G. Sanders, and K. Kline. 2004. Comparison of vitamin E derivatives, α-TEA and VES in reduction of mouse mammary tumor burden and metastasis. Experimental Biology and Medicine. 229: 954-963.

Lawson, K. A., K. Anderson, R. M. Snyder, M. Simmons-Menchaca, J. Atkinson, L-Z. Sun, A. Bandyopadhyay, V. Knight, B. E. Gilbert, B. G. Sanders and K. Kline. 2004. Novel vitamin E analogue and 9-nitro-camptothecin administered as liposome aerosols decrease syngeneic mouse mammary tumor burden and inhibit metastasis. Cancer
Chemotherapy and Pharmacology. 54:421-431.

Zhang, S., K. A. Lawson, M. Simmons-Menchaca, L-Z. Sun, B. G. Sanders, and K. Kline. 2004. Vitamin E analog α-TEA and celecoxib alone and together reduce human MDA-MB-435-FL-GFP breast cancer burden and metastasis in nude mice. Breast Cancer Research and Treatment. 87:111-121.

Anderson, K., M. Simmons-Menchaca, K. A. Lawson, J. A. Atkinson, B. G. Sanders and K. Kline. 2004. Differential response of human ovarian cancer cells to induction of apoptosis by vitamin E succinate and vitamin E analog, α-TEA. Cancer Research. 64:4263-4269.

Shun, M-C., W. Yu, A. Gapor, R. Parsons, J. Atkinson, B. G. Sanders, and K. Kline. 2004. Pro-apoptotic mechanisms of action of a novel vitamin E analog (α-TEA) and a naturally occurring form ofvitamin E (δ-tocotrienol) in MDA-MB-435 human breast cancer cells. Nutrition and Cancer. 48:95-105.

Yu, W., B. G. Sanders and K. Kline. 2003. RRR-α-tocopheryl succinate-induced apoptosis of human breast cancer cells involves Bax translocation to mitochondria. Cancer Research. 61: 2483-2491.Lawson, K.A., K. Anderson, M. Menchaca, J. Atkinson, L-Z. Sun, V. Knight, B.

E. Gilbert, C. Conti, B. G. Sanders, and K. Kline. 2003. Novel vitamin E analog decreases syngeneic mouse mammary tumor burden and reduces lung metastasis. Molecular Cancer Therapeutics 2: 437-444.

Yu, W., B. G. Sanders and K. Kline. 2002. RRR-α-tocopheryl succinate induction of DNA synthesis arrest of human MDA-MB-435 cells involves TGF-β independent activation of p21 (Waf1/Cip1). Nutrition and Cancer. 43: 227-236.

You, H., W. Yu, D. Munoz-Medellin, P. H. Brown, B. G. Sanders, and K. Kline. 2002. Role of extracellular signal-regulated kinase pathway in RRR-alpha-tocopheryl succinate-induced differentiation of human MDA-MB-435 breast cancer cells. Molecular Carcinogenesis 4: 228-236.